Pittsburgh at Chi. Cubs 2:20 PM ET
Pittsburgh Pirates fireballer Paul Skenes is producing stellar numbers during his sophomore season, even if his won-loss record isn't among them.
Toronto at Philadelphia 6:45 PM ET
Alejandro Kirk and the Toronto Blue Jays are carrying plenty of momentum into Friday's opener of a three-game road series against the Philadelphia Phillies.
Miami at Washington 6:45 PM ET
The Washington Nationals will try to carry over their performance late in a loss on Thursday when they open a three-game series against the visiting Miami Marlins on Friday night.
LA Angels at Baltimore 7:08 PM ET
The Baltimore Orioles didn't like the result in their most recent game, but certain developments might help set them up for their next series, which begins Friday against the visiting Los Angeles Angels.
Cincinnati at Detroit 7:10 PM ET
The Cincinnati Reds view this weekend as a measuring stick to see just how much they have improved.
Tampa Bay at NY Mets 7:10 PM ET
The New York Mets maintained the best record in the major leagues with a Thursday win over the Washington Nationals.
NY Yankees at Boston 7:10 PM ET
and they might have Giancarlo Stanton back in action this weekend.
Colorado at Atlanta 7:15 PM ET
Braves right-hander Bryce Elder will put his unbeaten record against the Colorado Rockies on the line Friday when the teams open a three-game series in Atlanta.
Chi. White Sox at Texas 8:05 PM ET
The Rangers' bats have finally come alive, and Texas will look to continue its recent scoring prowess when it faces the Chicago White Sox on Friday in the opener of a three-game series in Arlington, Texas.
Athletics at Kansas City 8:10 PM ET
It's been a month since the Athletics last won a road game.
Minnesota at Houston 8:10 PM ET
Houston Astros third baseman Isaac Paredes has provided a steady hand both at the plate and in the field this season, which made the sight of him limping off the field in the seventh inning on Thursday especially concerning.
St. Louis at Milwaukee 8:10 PM ET
The visiting St. Louis Cardinals will turn to right-hander Erick Fedde as they try to halt a five-game skid when they face the Milwaukee Brewers on Friday night.
San Diego at Arizona 9:40 PM ET
It has taken almost half a season, but the San Diego Padres and Arizona Diamondbacks will finally get a good look at each other when they meet in a three-game weekend series in Arizona.
Cleveland at Seattle 10:10 PM ET
Carlos Santana had contract offers from both the Cleveland Guardians and Seattle Mariners, two teams he had previously played for, this past offseason.
San Francisco at LA Dodgers 10:10 PM ET
After dispatching one second-place team during the week, the Los Angeles Dodgers will face another one when they host the San Francisco Giants on Friday in the start of a three-game weekend series.